Gaba

[speedlimit]

Hi all,

So i've been meaning to post on this board for a while but never got around to it and it's not like the website makes it easy to do so. Anyway I thought I should share some insight from my knowledge as a biochemist and my personal stuttering experience.

As we hear talk about Pagoclone and hope/demand for it, I researched the mechanism behind it. Basically like any anti-anxiety drug or alcohol to some extent, it increased your brain's receptivity to GABA, a inhibitory neurotransmitter. When you take a xanax, valium, lorazapam or drink etc, you're brain can uptake more and it helps control the firings (mis-firings the case of stutters) of the neurons in the brain. If any of you have noticed you are a bit more relaxed and fluent when on drugs, this is why.

What makes Pagoclone promising is it is specially formulated to work on GABA receptors and is a different class of drug compared to typical anxiety meds.

While not normally sold in stores, GABA, usually sold in a powder or capsuels, is available online. I buy mine from luckyvitamin.com. I have been taking either 5-7 750mg capsuels or 2 teaspoons of powder mixed into water or juice. It tends to take about 30 minutes to be absorbed and to feel a calming effect and sometimes helps when taken with a small amount of food.

I strongly reccomend you take a b-6 or b-complex vitamin along side it to help it absorb. Glutamine is also a precursor and helps it's effect but does not have a huge difference.

So that said. I have been taking my 5-7 pill or 2 teaspoon dose for about a year now and it has made a TON of difference. I've had the best effect taking a few doses throughout the day and a larger dose in the evening.

I wouldn't post here If I didn't believe this would totally help people as it did with me. PLEASE PLEASE PLEASE someone give this a shot and tell me how it goes!!!! Spread the word too if anyone is going to NSA meeting and such. This is by no means a cure but by far the best treatment I have found.

-Nick

[maverick75]

i dont need no treatment or cure....


i like my stuttering

[neuronknot]

Hello Nick,

Thanks for your useful post. I tried GABA powder (2 teaspoons) a day for 2 weeks. As well, took them with vitamin B-complex. I saw no results: neither short-term (meaning the same day) nor for the two-week duration.

How long did you have to take GABA before you saw any noticeable difference? And noticeable difference being that you felt more confident, more initiated, less inhibited, and of course more fluent?

I had relied on Xanax for my stuttering for over 7 years but then I stopped taking it. And to be fair, it did cause me to be all of the above (and did not give me a high or cause me to sleep), but I stopped taking it because of a major problem which it causes: amnesia.

That obviously causes a lot of problems for my business or for that matter socializing or even making friends. Because when I used to take Xanax, I accomplished a lot of things in that day, made deals, networked with a lot of people, went out, made friends, etc. But then the next day I would forget the details of the events, which are necessary to get things going in the long-run. And that would result in things not working out. So eventually I decided to stop taking it because what's the point of solving a problem which becomes a problem again the next day, in fact a worse problem, because now you have people who have tied high hopes with your demeanor, words, actions, and personality?

Tried recording devices, even hidden cameras, but it's was just too much hassle.

Tried SpeechEasy (which cost me around $5,000 in 2004 when I got it), but it had its own set of problems.

And of course, the good old (but useless) speech therapy sessions for over two years, in the beginning of my quest to find a solution to my stuttering.

~

I read that Pagoclone does not cause amnesia because it does not affect one of the three alpha receptors that Xanax does (I forget which one, but I think it was alpha-3). That became the main cause of my interest in Pagoclone.

Now, I also tried what you talked about (taking GABA powder/pills directly) but I did not see any immediate changes, so I thought it was a scam. In fact, I took GABA with L-Dopa Extract, which was recommended in the papers I researched. No effect at all.

That's why my questions to you:

1. For how long do you have to take GABA (by the way, the one I was taking was made by S.A.S Labs) to achieve the aforementioned results?

2. What is your view on taking L-Dopa Extract along with GABA?

3. Does it make a difference whether you take GABA two teaspoons all at once or as you said small doses during the day and a larger dose at night?

I would very much appreciate your detailed, logical, and medically evidence-backed responses (since you mentioned that you're a biochemist).

Thanks!

[speedlimit]

hey neuron dude,

So to answer your question the best I can. I took GABA for about 3 weeks before I got a regular postivie effect. It does take most anti-depressants and other neuro drugs like that a while to build up in your system. I'd say maybe go with 3 teaspoons (1 tablespoon) with a light meal and 1 teaspoon L-gultamine. I have never used L-dopa nor have heard anything about it. Xanax/Lorazapam/Ambien will cause amnesia if taken long term or a lot. They do the same thing as being really drunk basically.

Pagoclone is a different class of drug that enhances the GABA receptors. In our case with no pagolcone the only option next to the xanax etc is to flood the system with a lot of GABA. I'm small ~150s so 2-3 teapsoons GABA a couple times a day is enough for me. You may need more. ESPECIALLY if you have been using xanax etc for a while. Your receptors DO develop tolerance. That's why they are prescribed cautiously and considered addictive.
GABA is generally recogonized as safe. So there is no overdose. I've read bodybuilders taking up to 5-10g at once and worst case getting nausea.

Try 3-4 teaspoons. Write back in the morning. I myself have noticed tolerance after a few months but bump up the dose with some glutamine and B-complex. I have noticed 5-htp helps but I still am not sold. Keep at it man, let me know! Best of luck!

[urbanmermaid]

Originally Posted by neuronknot

Hello Nick,

Thanks for your useful post. I tried GABA powder (2 teaspoons) a day for 2 weeks. As well, took them with vitamin B-complex. I saw no results: neither short-term (meaning the same day) nor for the two-week duration.

How long did you have to take GABA before you saw any noticeable difference? And noticeable difference being that you felt more confident, more initiated, less inhibited, and of course more fluent?

I had relied on Xanax for my stuttering for over 7 years but then I stopped taking it. And to be fair, it did cause me to be all of the above (and did not give me a high or cause me to sleep), but I stopped taking it because of a major problem which it causes: amnesia.

That obviously causes a lot of problems for my business or for that matter socializing or even making friends. Because when I used to take Xanax, I accomplished a lot of things in that day, made deals, networked with a lot of people, went out, made friends, etc. But then the next day I would forget the details of the events, which are necessary to get things going in the long-run. And that would result in things not working out. So eventually I decided to stop taking it because what's the point of solving a problem which becomes a problem again the next day, in fact a worse problem, because now you have people who have tied high hopes with your demeanor, words, actions, and personality?

Tried recording devices, even hidden cameras, but it's was just too much hassle.

Tried SpeechEasy (which cost me around $5,000 in 2004 when I got it), but it had its own set of problems.

And of course, the good old (but useless) speech therapy sessions for over two years, in the beginning of my quest to find a solution to my stuttering.

~

I read that Pagoclone does not cause amnesia because it does not affect one of the three alpha receptors that Xanax does (I forget which one, but I think it was alpha-3). That became the main cause of my interest in Pagoclone.

Now, I also tried what you talked about (taking GABA powder/pills directly) but I did not see any immediate changes, so I thought it was a scam. In fact, I took GABA with L-Dopa Extract, which was recommended in the papers I researched. No effect at all.

That's why my questions to you:

1. For how long do you have to take GABA (by the way, the one I was taking was made by S.A.S Labs) to achieve the aforementioned results?

2. What is your view on taking L-Dopa Extract along with GABA?

3. Does it make a difference whether you take GABA two teaspoons all at once or as you said small doses during the day and a larger dose at night?

I would very much appreciate your detailed, logical, and medically evidence-backed responses (since you mentioned that you're a biochemist).

Thanks!

Xanax gave you amnesia.. you made friends and on the next day you didn't remember anything.. and tried hidden cameras but nothing worked?

LMAO!!!!!! You made my year

[mockin]

Hello everybody,

The past few days I have been doing some more research on stuttering and I stumbled upon this topic. I am a man of age 26 from the Netherlands. Since as long as I can remember I have had a stuttering problem, at least that's the way I think of it ( as a problem ). When I was a kid some of the other kids teased me every now and again but nothing serious. Can you blame them, it does sound funny when you try to say your name over the telephone as mi-mi-mi-mi-mike. The communication with my parents was quite hard some times since they were not the most patient of people. They saw it more as something my fault and that I just didn't try enough at being calm. At school on the playground I could manage just fine and my stutter was more like a stammer even standing in front of the class and giving a presentation about something I liked was not too bad. But reading out loud was the worst, I got nervous the second the teacher told us that that was what we were going to do. As I got older and reached puberty it got better and better, especially with people my own age. Ordering a bread at the bakery or trying to arrange stuff over the phone still scared the "shit" out of me though. And whenever I'm a bit stressfull it still causes me to lock-up and I have to find other words which do not cause me to stutter. A while ago I was asked to give a presentation in norway on my thesis subject ( numerical mathmatics ) and stand in front of an audience of postdocs and professors. I had been dreading this moment for a few monts so used a mild anti-anxiety drug called stablon, this helped me calm down but still I got nervous and indeed stammered my way through the presentiation.

When I came across this topic and read some more on Gaba I tried to give it a go and ordered the stuff. It came in today and this evening I took 4 grams of the stuff. And started preparing dinner, I didn't expect anything from it and wasn't actually thinking about it at all but suddenly I got nausea and a little short breathed. Suddenly it hit me that I must have been the Gaba. I had to sit down for 5 minutes but went back to prepare my dinner. Normally when I'm alone and talk to myself I can still stutter a bit ( especially in my head) or hang at certain words, so I thought lets try and speak to myself. But I noticed that my speech was really fluent and I could not get myself to hang , not even when I read text out loud for myself.

Ofcourse this could all be a placebo effect but I still thought it was worthwhile mentioning. I have my final presentiation in about 1,5 months which means presenting infront of my fellow students, family and friends, so I hope this stuff improves my speech as it did tonight.

I'll keep you posted,